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KMID : 0928520090190020183
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Korean Journal of Lipidology
2009 Volume.19 No. 2 p.183 ~ p.193
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Lipoprotein(a): Levels and Reference Intervals in Healthy Koreans
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Kim Won-Sool
Suh Byung-sung
Kim Dol-il
Cho Gang-hui
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Abstract
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Objective: Serum concentration of Lp(a) can be used as a risk factor indicator for cardiovascular disease. Lp(a) has been associated with anti-fibronolytic and athergenic effects. Population-based studies are needed to establish Lp(a) concentration reference intervals and reliable cut-off limits. The aim of this study was to provide the reference intervals, partitioned by age and gender, while also investigating relationships between Lp(a) and other atherogenic predictors in healthy Korean adults.
Methods: The population sample consisted of 37,121 healthy Korean adults (22,127 men and 14,994 women), between 20 and 69 years of age. Lp(a) concentration was measured by immunoturbidimetric assay.
Results: The geometric mean concentration of Lp(a) was 15.2 mg/dl and 17.3 mg/dl, in men and women, respectively. Lp(a) values were significantly affected by gender and age, while not affected by alcohol intake, smoking habits, and physical activity. The relationship of Lp(a) concentrations are comparatively lower with other atherogenic predictors except LDL-C, Apo B, and T-cholesterol.
Conclusion: The distribution of Lp(a) concentrations in Koreans was highly skewed toward lower levels. Lp(a) concentrations in Korean adults are different from other ethnic groups. Lp(a) values needed to be standardized with sex and age in order to be used as a predictor of atherogenic effect.
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KEYWORD
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Lipoprotein(a), Koreans, Reference value
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